Reaktion #961

Reaktionsgleichung

(3RS)-1-benzyl-3-hydroxymethyl pyrrolidine

thionyl chloride

→

(3RS)-1-benzyl-3-chloromethyl pyrrolidine

Lösungsmittel

CHCl3

CHCl3

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe mixture was evaporated
2. 2
   workup.DISSOLUTIONthe residue was dissolved in water

Vorschrift

To a refluxing solution of 15.3 g (0.08 mole) (3RS)-1-benzyl-3-hydroxymethyl pyrrolidine in 220 ml CHCl3 was slowly added a solution of 330 ml thionyl chloride in 60 ml CHCl3, and the reflux was continued for one hour. The mixture was evaporated and the residue was dissolved in water.

Quelle