Reaktion #960786

ord-0aa34a44a1384eb18a4266772699edbb

Reaktionsgleichung

Brc1cccnc1
3-bromopyridine
CC(C)(C)OC(=O)N1CCC(c2ccc(NC(=O)C3CNC3)cc2)CC1
tert-butyl 4-(4-(azetidine-3-carboxamido)phenyl)piperidine-1-carboxylate
CC(C)(C)OC(=O)N1CCC(Oc2ccc(NC(=O)C3CNC3)cc2)CC1
tert-butyl 4-(4-(azetidine-3-carboxamido)phenoxy)piperidine-1-carboxylate
→
Cc1nnccc1N1CC(C(=O)Nc2ccc(C3CCN(C(=O)OC(C)(C)C)CC3)cc2)C1
title compound
Cc1nnccc1N1CC(C(=O)Nc2ccc(C3CCN(C(=O)OC(C)(C)C)CC3)cc2)C1
tert-butyl 4-(4-(1-(3-methylpyridazin-4-yl)azetidine-3-carboxamido)phenyl)piperidine-1-carboxylate

Edukte

Brc1cccnc1
3-bromopyridine
CC(C)(C)OC(=O)N1CCC(c2ccc(NC(=O)C3CNC3)cc2)CC1
tert-butyl 4-(4-(azetidine-3-carboxamido)phenyl)piperidine-1-carboxylate
CC(C)(C)OC(=O)N1CCC(Oc2ccc(NC(=O)C3CNC3)cc2)CC1
tert-butyl 4-(4-(azetidine-3-carboxamido)phenoxy)piperidine-1-carboxylate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared as described in Example 1C, substituting 4-chloro-3-methylpyridazine for 3-bromopyridine and tert-butyl 4-(4-(azetidine-3-carboxamido)phenyl)piperidine-1-carboxylate for tert-butyl 4-(4-(azetidine-3-carboxamido)phenoxy)piperidine-1-carboxylate.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08975398B2uspto-grants-2015_03