Reaktion #960777

ord-3839948986cb41ffa2d667e71deb3992

Reaktionsgleichung

CC(C)(C)OC(=O)N1CCC(c2ccc(NC(=O)C3CNC3)cc2)CC1
tert-butyl 4-(4-(azetidine-3-carboxamido)phenyl)piperidine-1-carboxylate
Fc1ccc(F)nn1
3,6-difluoropyridazine
Clc1ccc(Cl)nn1
3,6-dichloropyridazine
→
CC(C)(C)OC(=O)N1CCC(c2ccc(NC(=O)C3CN(c4ccc(F)nn4)C3)cc2)CC1
title compound
CC(C)(C)OC(=O)N1CCC(c2ccc(NC(=O)C3CN(c4ccc(F)nn4)C3)cc2)CC1
tert-butyl 4-(4-(1-(6-fluoropyridazin-3-yl)azetidine-3-carboxamido)phenyl)piperidine-1-carboxylate

Edukte

CC(C)(C)OC(=O)N1CCC(c2ccc(NC(=O)C3CNC3)cc2)CC1
tert-butyl 4-(4-(azetidine-3-carboxamido)phenyl)piperidine-1-carboxylate
Fc1ccc(F)nn1
3,6-difluoropyridazine
Clc1ccc(Cl)nn1
3,6-dichloropyridazine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared as described in Example 147A, substituting tert-butyl 4-(4-(azetidine-3-carboxamido)phenyl)piperidine-1-carboxylate for tert-butyl 4-(4-(azetidine-3-carboxamido)phenyl)piperidine-1-carboxylate and 3,6-difluoropyridazine for 3,6-dichloropyridazine.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08975398B2uspto-grants-2015_03