Reaktion #960761

ord-145fa5f2e9754fef8d7a579fc4f9399b

Reaktionsgleichung

CC(C)(C)OC(=O)N1CCC(c2ccc(NC(=O)C3CCN(c4ccc(Cl)nn4)CC3)cc2)CC1
tert-butyl 4-(4-(1-(6-chloropyridazin-3-yl)piperidine-4-carboxamido)phenyl)piperidine-1-carboxylate
O=C(Nc1ccc(C2CCN(C(=O)[O-])CC2)cc1)C1CN(c2ccc(Cl)nn2)C1
4-(4-(1-(6-chloropyridazin-3-yl)azetidine-3-carboxamido)phenyl)piperidine-1-carboxylate
→
CC(C)(C)OC(=O)N1CCC(c2ccc(NC(=O)C3CCN(c4cccnn4)CC3)cc2)CC1
title compound
CC(C)(C)OC(=O)N1CCC(c2ccc(NC(=O)C3CCN(c4cccnn4)CC3)cc2)CC1
tert-butyl 4-(4-(1-(pyridazin-3-yl)piperidine-4-carboxamido)phenyl)piperidine-1-carboxylate

Edukte

CC(C)(C)OC(=O)N1CCC(c2ccc(NC(=O)C3CCN(c4ccc(Cl)nn4)CC3)cc2)CC1
tert-butyl 4-(4-(1-(6-chloropyridazin-3-yl)piperidine-4-carboxamido)phenyl)piperidine-1-carboxylate
O=C(Nc1ccc(C2CCN(C(=O)[O-])CC2)cc1)C1CN(c2ccc(Cl)nn2)C1
4-(4-(1-(6-chloropyridazin-3-yl)azetidine-3-carboxamido)phenyl)piperidine-1-carboxylate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared as described in Example 147B, tert-butyl 4-(4-(1-(6-chloropyridazin-3-yl)piperidine-4-carboxamido)phenyl)piperidine-1-carboxylate for 4-(4-(1-(6-chloropyridazin-3-yl)azetidine-3-carboxamido)phenyl)piperidine-1-carboxylate.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08975398B2uspto-grants-2015_03