Reaktion #960237

ord-90ce81ab3ce4473797648199ec6e7e8b

Reaktionsgleichung

CC(C)(C)OC(=O)N1CCn2c1cc(Cl)nc2=O
tert-butyl 7-chloro-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate
N#Cc1cccc(CO)c1
3-(hydroxymethyl)benzonitrile
[H-].[Na+]
sodium hydride
→
CC(C)(C)OC(=O)N1CCn2c1cc(OCc1cccc(C#N)c1)nc2=O
title compound
CC(C)(C)OC(=O)N1CCn2c1cc(OCc1cccc(C#N)c1)nc2=O
tert-butyl 7-((3-cyanobenzyl)oxy)-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate

Edukte

CC(C)(C)OC(=O)N1CCn2c1cc(Cl)nc2=O
tert-butyl 7-chloro-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate
—
E1
N#Cc1cccc(CO)c1
3-(hydroxymethyl)benzonitrile
[H-].[Na+]
sodium hydride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared by a procedure similar to that described for E1 starting from 3-(hydroxymethyl)benzonitrile, sodium hydride and tert-butyl 7-chloro-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08975400B2uspto-grants-2015_03