Reaktion #960146

Reaktionsgleichung

Water

2,4,5-trifluoronitrobenzene

benzyl alcohol

K2CO3

→

title compound

Ausbeute 74.2%

1-(benzyloxy)-2,5-difluoro-4-nitrobenzene

Ausbeute 74.2%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGthe resulted mixture was further stirred at 4° C. for 24 hours
2. 2
   FiltrationThe solid was collected by filtration
3. 3
   Waschenwashed with 30 mL of water
4. 4
   Sonstigedried in vacuo at 45° C.

Vorschrift

To a solution of 2,4,5-trifluoronitrobenzene (5.4 g, 30.5 mmol) and benzyl alcohol (3.2 mL, 30.5 mmol) in DMF (20 mL) was added K2CO3 (6.33 g, 46.1 mmol). The reaction was stirred at room temperature for 72 hours. Water (60 mL) was added at 0° C. and the resulted mixture was further stirred at 4° C. for 24 hours. The solid was collected by filtration, washed with 30 mL of water, and dried in vacuo at 45° C. to provide the title compound as a pale yellow solid (6.0 g, 74%).

Quelle