Reaktion #95992

Reaktionsgleichung

6-Bromooxazolo[4,5-b]pyridine-2(3H)-one

sodium hydroxide

HCl

→

tan crystals

Ausbeute 52.9%

2-Amino-5-bromo-3-pyridinol

Ausbeute 52.9%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe resulting solid was collected by filtration
2. 2
   Waschenwashed with water
3. 3
   Sonstigedried
4. 4
   SonstigeRecrystallization from aqueous ethanol

Vorschrift

6-Bromooxazolo[4,5-b]pyridine-2(3H)-one (K. Rufenacht and H. Kristinsson, Helv. Chim. Acta 59 (5), 1593 [1976]) (4.3 g; 0.02 mole) sodium hydroxide (5 g; 0.125 mole) and water (50 ml) were stirred on the steam bath for 45 minutes. The solution was cooled to approximately 10° C. and carefully acidified with concentrated HCl (considerable foaming). The resulting solid was collected by filtration, washed with water and dried. The yield was 3.0 g (79 percent) of tan solid melting at 187° to 189° C. Recrystallization from aqueous ethanol afforded 2.0 g of tan crystals, melting point 195° to 197° C.

Quelle