Reaktion #95970

Reaktionsgleichung

4-benzyl-1-cyano-1-(dimethylamino)cyclohexane

LAH

water

sodium hydroxide

water

→

(1-aminomethyl-4-benzyl-1-cyclohexyl)dimethylamine

Lösungsmittel

diethyl ether

diethyl ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooled in an ice-methanol bath
2. 2
   SonstigeThe inorganic gel was collected on a filter
3. 3
   Einengenthe filtrate was concentrated in vacuo

Vorschrift

A solution of 9.5 mmole of 4-benzyl-1-cyano-1-(dimethylamino)cyclohexane in 25 ml of diethyl ether was added to a suspension of 0.40 g of LAH in 10 ml of diethyl ether cooled in an ice-methanol bath. Following 4 hours' stirring at 20° to 25° C., the mixture was treated in turn with 0.4 ml of water, 0.4 ml of 15% sodium hydroxide and 1.2 ml of water. The inorganic gel was collected on a filter, and the filtrate was concentrated in vacuo to give (1-aminomethyl-4-benzyl-1-cyclohexyl)dimethylamine was a viscous gum.

Quelle