Reaktion #95946

ord-53068da6218c4df7a8839381c2a1f811

Reaktionsgleichung

CCOC(=O)CC(C)=O
ethyl acetoacetate
O
water
NCCNCCN
diethylenetriamine
CC(C)CCCCCCCCCCCCCCC(=O)O
isostearic acid
→
CC1=NCCN(CCNC(=O)CCCCCCCCCCCCCCC(C)C)C(=O)C1
4-isostearamidoethyl-7-methyl-3,6-dihydro-2H-1,4-diazepin-5-one

Edukte

CCOC(=O)CC(C)=O
ethyl acetoacetate
O
water
NCCNCCN
diethylenetriamine
CC(C)CCCCCCCCCCCCCCC(=O)O
isostearic acid

Reagenzien

Keine

Lösungsmittel

CCO
ethanol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    workup.DISTILLATIONAt 200° to 210° C., 18 g of water was distilled off
  2. 2
    workup.DISTILLATIONwere distilled off at 150° to 160° C.

Vorschrift

Into an apparatus similar to that in Example 1, were charged 103.1 g (1 mole) of diethylenetriamine and 284.5 g (1 mole) of isostearic acid. At 200° to 210° C., 18 g of water was distilled off to effect the monoamide formation. Then, after the addition of 130.1 g (1 mole) of ethyl acetoacetate, 18 g of water and 46 g of ethanol were distilled off at 150° to 160° C. to obtain 4-isostearamidoethyl-7-methyl-3,6-dihydro-2H-1,4-diazepin-5-one.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04346087uspto-grants-1982_08