Reaktion #95945

Reaktionsgleichung

diethylenetriamine

methyl acetoacetate

oleic acid

→

4-oleamidoethyl-7-methyl-3,6-dihydro-2H-1,4-diazepin-5-one

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.DISTILLATIONAt 110° to 120° C. and under a reduced pressure of 70 mmHg, 18 g of water and 32 g of methanol were distilled off
2. 2
   Sonstigewas effected at 210° to 215° C.
3. 3
   Sonstigeto distil off 18 g of water

Vorschrift

Into an apparatus similar to that in Example 1, were charged 103.1 g (1 mole) of diethylenetriamine and 116.1 g (1 mole) of methyl acetoacetate. At 110° to 120° C. and under a reduced pressure of 70 mmHg, 18 g of water and 32 g of methanol were distilled off. Then, with the addition of 282.5 g (1 mole) of oleic acid, the amide formation was effected at 210° to 215° C. to distil off 18 g of water and to obtain 4-oleamidoethyl-7-methyl-3,6-dihydro-2H-1,4-diazepin-5-one.

Quelle