Reaktion #95934

Reaktionsgleichung

1-(7-carboxy-7-hydroxyheptyl)imidazole hydrochloride

thionyl chloride

→

title compound

1-(7-carboxy-7-chloroheptyl)imidazole hydrochloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenconcentrated under reduced pressure
2. 2
   workup.ADDITIONIce was added to the obtained residue
3. 3
   workup.STIRRINGthe mixture was stirred for 5 minutes
4. 4
   Einengenconcentrated under reduced pressure
5. 5
   workup.ADDITIONA small amount of water was added to the residue, and insoluble materials
6. 6
   Sonstigewere removed off
7. 7
   Sonstigethe solution thus obtained
8. 8
   Einengenwas concentrated under reduced pressure

Vorschrift

To 140 mg of 1-(7-carboxy-7-hydroxyheptyl)imidazole hydrochloride (prepared in Example 6(a)) was added dropwise 0.193 ml of thionyl chloride at from 0° C. to 3° C., and the mixture was stirred at room temperature overnight, and concentrated under reduced pressure. Ice was added to the obtained residue, and the mixture was stirred for 5 minutes, and concentrated under reduced pressure. A small amount of water was added to the residue, and insoluble materials were removed off, and the solution thus obtained was concentrated under reduced pressure to give 149 mg of the title compound having the following physical characteristics:

Quelle