Reaktion #9593

Reaktionsgleichung

7-bromo-4-chloro-3-nitroquinoline

ethylenediamine

→

N1-(7-bromo-3-nitroquinolin-4-yl)ethane-1,2-diamine

Lösungsmittel

DMF

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe reaction was quenched with 2 L water
2. 2
   workup.STIRRINGstirred for an additional hour
3. 3
   workup.ADDITIONAdditional water was added
4. 4
   workup.STIRRINGthe mixture was stirred overnight
5. 5
   SonstigeA precipitate formed
6. 6
   Sonstigewas isolated by filtration
7. 7
   Sonstigeair-dried overnight on the filter funnel

Vorschrift

A solution of 7-bromo-4-chloro-3-nitroquinoline (143.8 g, 0.5 mol) in 800 mL warm DMF was added to a stirred solution of ethylenediamine in 200 mL DMF at room temperature; the reaction was stirred at room temperature overnight. The reaction was quenched with 2 L water and stirred for an additional hour. Additional water was added, and the mixture was stirred overnight. A precipitate formed and was isolated by filtration and air-dried overnight on the filter funnel to provide N1-(7-bromo-3-nitroquinolin-4-yl)ethane-1,2-diamine as a yellow solid.

Quelle