Reaktion #959162

Reaktionsgleichung

N,N-dimethylformamide

4-bromo-3-methoxyphenol

potassium carbonate

→

compound

Ausbeute 69.0%

2-Bromo-5-methoxymethoxyanisole

Ausbeute 69.0%

Lösungsmittel

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling down
2. 2
   WaschenThe mixture was washed with water (150 mL) and saturated brine (50 mL) successively
3. 3
   Trocknendried over anhydrous magnesium sulfate
4. 4
   Sonstigethe solvent was removed under reduced pressure
5. 5
   SonstigeThe obtained residue was purified by silica gel column chromatography (hexane-ethyl acetate)

Vorschrift

A mixture of 4-bromo-3-methoxyphenol (500 mg, 2.46 mmol), chlorodimethylether (281 μL, 3.70 mmol), and potassium carbonate (850 mg, 6.15 mmol) was suspended in anhydrous N,N-dimethylformamide (8 mL) and stirred at 50° C. for 1 hour. After cooling down, the reaction mixture was diluted with ethyl acetate (150 mL). The mixture was washed with water (150 mL) and saturated brine (50 mL) successively, dried over anhydrous magnesium sulfate, and then the solvent was removed under reduced pressure. The obtained residue was purified by silica gel column chromatography (hexane-ethyl acetate) to give the titled reference compound (421 mg) as a colorless oil. (Yield 69%)

Quelle