Reaktion #957466

Reaktionsgleichung

thionyl chloride

lipoic acid

→

(±)-5-(1,2-dithiolan-3-yl)pentanoyl chloride

Lösungsmittel

dichloromethane

CH2Cl2

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter completion of the reaction the solvent
2. 2
   Sonstigewas removed under vacuum
3. 3
   Sonstigea dry-ice collection trap
4. 4
   Temperaturto heat the reaction mixture since
5. 5
   SonstigeReaction

Vorschrift

To a stirred solution of thionyl chloride (1.4 mL, 7.5 mmol) in CH2Cl2 (30 ml) at 0° C. was added a solution of lipoic acid (3.0 g, 5 mmol), dissolved in dichloromethane, dropwise over 1 h. The mixture was allowed to stir for additional 3 h. at the same temperature. After completion of the reaction the solvent was removed under vacuum using a dry-ice collection trap being very careful not to heat the reaction mixture since this will decompose the product. Reaction proceeds with quantitative yield.

Quelle