Reaktion #956984

Reaktionsgleichung

2-chloro-5-fluoro-4-methylbenzoic acid

potassium nitrate

→

subtitle compound

Ausbeute 102.5%

2-Chloro-5-fluoro-4-methyl-3-nitro-benzoic acid

Ausbeute 102.5%

Lösungsmittel

sulfuric acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe reaction mixture was quenched with ice water
2. 2
   Sonstigethe precipitate was collected
3. 3
   Sonstigedried in vacuo

Vorschrift

A solution of 2-chloro-5-fluoro-4-methylbenzoic acid (Preparation 1b, 51.57 g) dissolved in conc sulfuric acid (143 mL) was treated with potassium nitrate (32.4 g) portionwise over 10 min at 0° C. under nitrogen. The resulting mixture was allowed to warm to room temperature before stirring at 50° C. for 1 h. The reaction mixture was quenched with ice water and the precipitate was collected and dried in vacuo to afford the subtitle compound (65.5 g).

Quelle