Reaktion #956099

Reaktionsgleichung

2-methylbenzo[d]oxazole

dimethyl acetamide

→

title compound

Ausbeute 51.7%

(E)-2-(Benzo[d]oxazol-2-yl)-N,N-dimethylethenamine

Ausbeute 51.7%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with EtOAc (100 mL×2)
2. 2
   WaschenThe organic phase was washed
3. 3
   Sonstigedried
4. 4
   Einengenconcentrated
5. 5
   SonstigeThe residue was purified by column chromatography

Vorschrift

A mixture of 2-methylbenzo[d]oxazole (3 g, 22.6 mmol) in DMF (3.2 g) and dimethyl acetamide (3.5 g, 29.3 mmol) was stirred under N2 at 145° C. overnight. Then the solution was poured into ice-water and extracted with EtOAc (100 mL×2). The organic phase was washed, dried and concentrated. The residue was purified by column chromatography to get the title compound (2.2 g). MS (ESI) m/z 134 (M+H+).

Quelle