Reaktion #955972

Reaktionsgleichung

4-aminobiphenyl

4-bromo-1,1′:3′,1″-terphenyl

sodium tert-butoxide

→

white solid

Ausbeute 74.3%

N-([1,1′-biphenyl]-4-yl)-[1,1′:3′,1″-terphenyl]-4-amine

Ausbeute 74.3%

Lösungsmittel

toluene

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONThe catalyst solution was added to the reaction mixture
2. 2
   workup.STIRRINGstirred for 2 minutes
3. 3
   SonstigeFlask was capped
4. 4
   workup.WAITleft
5. 5
   workup.STIRRINGto stir in the drybox overnight at room temperature
6. 6
   SonstigeNext day, reaction mixture
7. 7
   Filtrationfiltered through a one-inch plug of silica gel
8. 8
   Waschenwashing with 500 ml of dichloromethane
9. 9
   SonstigeRemoval of volatiles under reduced pressure
10. 10
    Sonstigegave a yellow solid
11. 11
    SonstigeCrude product was purified by trituration with diethyl ether

Vorschrift

In a drybox, 4-aminobiphenyl (0.542 g) and 4-bromo-1,1′:3′,1″-terphenyl (0.89 g) were combined in a round-bottom flask and dissolved in 10 ml of dry toluene. Tris(tert-butyl)phosphine (0.022 g, 0.11 mmol) and tris(dibenzylideneacetone) dipalladium(0) (0.05 g, 0.055 mmol) were dissolved in 10 ml of dry toluene and stirred for 5 minutes. The catalyst solution was added to the reaction mixture, stirred for 2 minutes and was followed by sodium tert-butoxide (0.32 g, 3.3 mmol). Flask was capped and left to stir in the drybox overnight at room temperature. Next day, reaction mixture was taken out of the box and filtered through a one-inch plug of silica gel topped with celite, washing with 500 ml of dichloromethane. Removal of volatiles under reduced pressure gave a yellow solid. Crude product was purified by trituration with diethyl ether to give 0.85 g (73%) of a white solid. Structure was confirmed by 1H NMR spectroscopy.

Quelle