Reaktion #955938

Reaktionsgleichung

4-chloro-2-methoxybenzoic acid

MeOH

→

methyl 4-chloro-2-methoxybenzoate

Ausbeute 96.0%

Lösungsmittel

H2SO4

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas refluxed overnight
2. 2
   SonstigeMeOH was evaporated
3. 3
   Extraktionthe residue was extracted to EtOAc
4. 4
   Waschensuccessively washed with water and brine
5. 5
   Trocknendried over MgSO4
6. 6
   Filtrationfiltered
7. 7
   Sonstigeevaporated

Vorschrift

A suspension of 4-chloro-2-methoxybenzoic acid (5 g, 27 mmol) in MeOH (18 mL) and conc. H2SO4 (1.5 mL) was refluxed overnight. MeOH was evaporated and the residue was extracted to EtOAc and successively washed with water and brine, dried over MgSO4, filtered and evaporated to give methyl 4-chloro-2-methoxybenzoate as a white solid (5.17 g, 96%).

Quelle