Reaktion #955093

Reaktionsgleichung

lithium aluminium hydride

ethyl-1-(4-ethoxyphenyl)-2,2-difluorocyclopropane-1-carboxylate

water

NaOH

water

→

colourless oil

Ausbeute 92.0%

1-(4-ethoxyphenyl)-2,2-difluorocyclopropane-1-methanol

Ausbeute 92.0%

Lösungsmittel

ether

ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONare added
2. 2
   FiltrationThe solid precipitate is filtered off
3. 3
   Waschenwashed with ether
4. 4
   Sonstigethe combined filtrates dried
5. 5
   Einengenconcentrated under reduced pressure

Vorschrift

To 1.0 g of lithium aluminium hydride in 120 ml of dry ether, at room temperature is added dropwise 5.4 g (0.02 moles) of ethyl-1-(4-ethoxyphenyl)-2,2-difluorocyclopropane-1-carboxylate in 20 ml of ether. The reaction mixture is stirred for 1 hr after which 1.0 ml of water 1.0 ml of 15% NaOH, followed by 3.0 ml of water are added. The solid precipitate is filtered off, washed with ether and the combined filtrates dried and concentrated under reduced pressure to yield (4.2 g) a colourless oil; nD 1.5129.

Quelle