Reaktion #955

Reaktionsgleichung

4-hydroxyethyl piperidine

N-benzyloxycarbonyl-S-methyl isothiourea

→

title compound

Ausbeute 41.0%

1-Benzyloxycarbonylamidino-4-hydroxyethyl piperidine

Ausbeute 41.0%

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas refluxed overnight
2. 2
   SonstigeEvaporation and flash chromatography on silica gel with ethyl acetate

Vorschrift

A mixture of 6.2 g (0.028 mol) of 4-hydroxyethyl piperidine and 3.6 g (0.028 mol) of N-benzyloxycarbonyl-S-methyl isothiourea in 50 ml of acetonitrile was refluxed overnight. Evaporation and flash chromatography on silica gel with ethyl acetate gave 3.5 g (41%) of the title compound.

Quelle