Reaktion #95495

Reaktionsgleichung

ether

6-chloro-1-(2-chlorophenyl)-1'-methylspiro[indoline-3,4'-piperidine]

phenyl chloroformate

→

6-chloro-1-(2-chlorophenyl)-1'-phenoxycarbonylspiro[indoline-3,4'-piperidine]

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   WaschenThereafter, the mixture is successively washed with 10% sodium hydroxide
2. 2
   Waschenwashed with water
3. 3
   Sonstigedried
4. 4
   Einengenconcentrated under vacuum
5. 5
   Sonstigeleaving a brownish oil

Vorschrift

A mixture of 0.8 g of 6-chloro-1-(2-chlorophenyl)-1'-methylspiro[indoline-3,4'-piperidine], free base of Example 28, and 0.5 g of phenyl chloroformate in 20 ml of methylene chloride is stirred at ambient temperature for 16 hours. Thereafter, the mixture is successively washed with 10% sodium hydroxide, washed with water, dried and concentrated under vacuum leaving a brownish oil. The oil is passed through an alumina column, ether eluant, providing a colorless gum of 6-chloro-1-(2-chlorophenyl)-1'-phenoxycarbonylspiro[indoline-3,4'-piperidine]. IR and NMR spectra confirm the assigned structure.

Quelle