Reaktion #954600

Reaktionsgleichung

D-penicillamine

4-methylbenzaldehyde

→

crude title acid

5,5-Dimethyl-2-(4-methylphenyl)-thiazolidine-4(S)-carboxylic acid

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe precipitated crystals are filtered out
2. 2
   Waschenwashed with 30% methanol

Vorschrift

A solution containing 1.50 g (10 mmoles) of D-penicillamine and 1.18 ml (10 mmoles) of 4-methylbenzaldehyde in 30 ml of 30% methanol is stirred for 1 hour. The precipitated crystals are filtered out and washed with 30% methanol to give the crude title acid in a yield of 2.25 g (89.5%) which can be recrystallized from methanol by adding water, m.p.: 89°-90° C., [α]D =+53.5 (c=0.784, dimethylsulphoxide).

Quelle