Reaktion #954526

ord-09ad07959c3148449917ba0e772ef309

Reaktionsgleichung

CCCc1nc2ccc(I)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)(C)C)cc1
CCCc1nc2ccc(I)cc2c(=
C1CCNCC1
C1CCNCC1
→
CCCc1nc2ccc(N3CCCCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)(C)C)cc1
CCCc1nc2ccc(N3CCCCC3
Ausbeute 61.0%

Edukte

CCCc1nc2ccc(I)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)(C)C)cc1
CCCc1nc2ccc(I)cc2c(=O)n1Cc1ccc
C1CCNCC1
C1CCNCC1

Reagenzien

O=P([O-])([O-])[O-].[K+].[K+].[K+]
O=P([O-])([O-])[O-].[K+].[K+].
[Cu][I]
[Cu][I]
O=C(O)C(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1
O=C(O)C(=O)Nc1cc(C(F)(F)F)cc(C

Lösungsmittel

CS(C)=O
CS(C)=O
CS(C)=O
CS(C)=O

Reaktionsbedingungen

Temperatur
80°CELSIUS

Aufarbeitung

  1. 1
    workup.ADDITIONThe reaction vials were then cooled to r.t. and diluted with 100 μL of 5% AcOH in DMSO, containing 1,3,5-trimethoxybenzene (0.005M) and were shaken vigorously.
  2. 2
    workup.ALIQUOT25 microliter of resulting solution is taken
  3. 3
    workup.ADDITIONTo the 25 microliter aliquot 700 microliter of MeCN was added prior to UPLC-MS Analysis

Quelle

DOI: 10.1039/C5SC04751JFigure 4 from Chemistry informer libraries