Reaktion #954220

Reaktionsgleichung

3-(3-bromophenyl)-1-methyl-5-phenyl-4(1H)-pyridinone

pyridinone

lithium aluminum hydride

→

3-(3-bromophenyl)-1-methyl-5-phenyl-4-piperidinone

Lösungsmittel

2-propanone

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas chromatographed

Vorschrift

A 10 g. portion of 3-(3-bromophenyl)-1-methyl-5-phenyl-4(1H)-pyridinone was made from 22 g. of the corresponding 2-propanone as described in Examples 1-3. The pyridinone was reduced with 2 g. of lithium aluminum hydride as described in the examples above, and the reaction mixture was chromatographed as described above with benzene-ethyl acetate mixtures. The combined yield of the compounds of Examples 13 and 13a was 4 g., molecular weight 341 by mass spectroscopy. The yield of the compound of Example 14 was 0.5 g., molecular weight by mass spectroscopy 343.

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