Reaktion #95388

Reaktionsgleichung

1-(2-acetoxyethyl)pyrrole

pyridine

ethoxalyl chloride

→

ethyl 1-(2-acetoxyethyl)pyrrole-2-glyoxylate

Lösungsmittel

dichloromethane

dichloromethane

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeremains at about -20° to -25° C
2. 2
   workup.ADDITIONis added while the temperature
3. 3
   Temperaturis maintained at temperatures of about 0° to -20° C
4. 4
   WaschenWashing with water
5. 5
   Sonstigedrying
6. 6
   Sonstigeremoval of the solvent and purification

Vorschrift

In the next step, a solution of pyridine in anhydrous dichloromethane is added to a stirred and cooled solution of ethoxalyl chloride in anhydrous dichloromethane so that the reaction temperature remains at about -20° to -25° C. Upon completion of this addition an approximately equimolar amount of 1-(2-acetoxyethyl)pyrrole of Formula (III) in anhydrous dichloromethane is added while the temperature is maintained at temperatures of about 0° to -20° C. Washing with water, drying, removal of the solvent and purification gives ethyl 1-(2-acetoxyethyl)pyrrole-2-glyoxylate.

Quelle