Reaktion #953815

ord-919c8c4fc6f4486f8446f8950a4637d0

Reaktionsgleichung

NCc1ccccc1
benzylamine
C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](C)P(=O)(O)O
(1R)-1-[(N-benzyloxycarbonyl-L-alanyl)amino]-ethylphosphonic acid
→
C[C@H](N)C(=O)N[C@@H](C)P(=O)(O)O
(1R)-1-(L-alanylamino)-ethylphosphonic acid

Edukte

NCc1ccccc1
benzylamine
C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](C)P(=O)(O)O
(1R)-1-[(N-benzyloxycarbonyl-L-alanyl)amino]-ethylphosphonic acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

In a manner analogous to that described in the last paragraph of Example A, starting from the benzylamine salt of (1R)-1-[(N-benzyloxycarbonyl-L-alanyl)amino]-ethylphosphonic acid there was obtained (1R)-1-(L-alanylamino)-ethylphosphonic acid of melting point 295°-296° C (decomposition); [α]D20 = -45.6° (c = 1% in water).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04100275uspto-grants-1978_07