Reaktion #953680

Reaktionsgleichung

(phenylthio)carbonyl chloride

sodium hydroxide

1-amino-2-imidazolidinone

dioxane

sodium hydroxide

dioxane

→

(2-Oxo-1-imidazolidinyl)carbamothioic Acid, S-Phenyl Ester

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.DISTILLATIONThe dioxane is then distilled off
2. 2
   SonstigeAn oil separates which crystallizes after a short while
3. 3
   Sonstigeto give 3.2 g
4. 4
   Sonstigeof (2-oxo-1-imidazolidinyl)carbamothioic acid, S-phenyl ester, m.p. 154°-159° (after recrystallization from ethyl acetate)

Vorschrift

3.2 ml. of (phenylthio)carbonyl chloride are dissolved in 30 ml. of dioxane and a solution of 2.63 g. of 1-amino-2-imidazolidinone in a mixture of 10 ml. of dioxane and 10 ml. of water is added. 2N sodium hydroxide solution is added dropwise at room temperature so that the pH is about 7.5-8.0. About 15 ml. of 2N sodium hydroxide are required. The dioxane is then distilled off. An oil separates which crystallizes after a short while to give 3.2 g. of (2-oxo-1-imidazolidinyl)carbamothioic acid, S-phenyl ester, m.p. 154°-159° (after recrystallization from ethyl acetate).

Quelle