Reaktion #953047

Reaktionsgleichung

azodicarboxylate

4-propylphenol

6-bromo-1-hexanol

triphenylphosphine

triphenylphosphine

diisopropylazodicarboxylate

→

title compound

Ausbeute 67.0%

1-[(6-Bromohexyl)oxy]-4-propylbenzene

Ausbeute 67.0%

Lösungsmittel

THF

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe slightly yellow reaction
2. 2
   workup.ADDITIONwas added
3. 3
   workup.ADDITIONwas added
4. 4
   EinengenThe mixture was concentrated in vacuo
5. 5
   Sonstigethe white powder obtained
6. 6
   Sonstigewas purified by flash chromatography on silica gel (150 g)
7. 7
   Wascheneluted with a step gradient of hexane to 2:98 EtOAc/hexane
8. 8
   SonstigeThe slightly impure product obtained
9. 9
   Sonstigewas rechromatographed on silica gel (150 g)
10. 10
    Wascheneluted with 1:99 EtOAc/hexane

Vorschrift

A solution of diisopropylazodicarboxylate (2.12 g, 10.5 mmol) in THF (25 mL) was added via syringe pump over 1.5 h to a mixture of 4-propylphenol (purchased from Aldrich Chemical Co.) (1.36 g, 10.0 mmol), 6-bromo-1-hexanol (purchased from Aldrich Chemical Co.) (1.81 g, 10.0 mmol), and triphenylphosphine (2.75 g, 10.5 mmol) in THF (25 mL) at 0° C. under argon. The slightly yellow reaction was stirred at 0° C. for 30 min, whereupon additional triphenylphosphine (262 mg, 1.00 mmol) was added, followed by addition of diisopropyl-, azodicarboxylate (200 mL, 1.0 mmol) over 30 min. The reaction was allowed to warm to RT, at which time silica gel (15 g) was added. The mixture was concentrated in vacuo and the white powder obtained was purified by flash chromatography on silica gel (150 g) eluted with a step gradient of hexane to 2:98 EtOAc/hexane. The slightly impure product obtained was rechromatographed on silica gel (150 g) eluted with 1:99 EtOAc/hexane to give title compound (2.00 g, 67%) as a colorless oil.

Quelle