Reaktion #95276

Reaktionsgleichung

sodium iodide

1-chloro-trans-1-octen 3-one

1-chloro-trans-1-octen-3-one

→

1-iodo-trans-1-octen-3-one

Lösungsmittel

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONA mixture of 54.5 g
2. 2
   Temperaturrefluxed for 24 hours
3. 3
   TemperaturThe reaction mixture is cooled
4. 4
   Filtrationfiltered
5. 5
   Einengenconcentrated
6. 6
   SonstigeThe residue is partitioned between water and ether
7. 7
   WaschenThe organic phase is washed with dilute sodium bicarbonate solution, brine
8. 8
   Trocknendried (MgSO4)
9. 9
   Sonstigeevaporated to an oil
10. 10
    SonstigeThis material is used directly without purification

Vorschrift

A mixture of 54.5 g. (0.364 mole) of sodium iodide and 40 g. (0.249 mole) of 1-chloro-trans-1-octen 3-one (Example 723) in 360 ml. of acetone is stirred and refluxed for 24 hours. The reaction mixture is cooled, filtered and concentrated. The residue is partitioned between water and ether. The organic phase is washed with dilute sodium bicarbonate solution, brine, dried (MgSO4) and evaporated to an oil. This material is used directly without purification.

Quelle