Reaktion #95237

Reaktionsgleichung

sodium

Methylacetate

sodium

Ethyldiethoxyacetate

methylacetate

sodium

→

methyl γ,γ-diethoxyacetoacetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeequipped with stirrer
2. 2
   Temperaturreflux condenser
3. 3
   Temperaturheated to reflux
4. 4
   Temperaturheating
5. 5
   workup.DISSOLUTIONis completely dissolved
6. 6
   Temperaturheating
7. 7
   TemperaturThe mixture is cooled
8. 8
   Extraktionthe mixture extracted with ether
9. 9
   Sonstigeis acidified with hydrochloric acid at 10° C. to 15° C.
10. 10
    Extraktionthe desired product extracted with ether
11. 11
    ExtraktionThe ethereal extract
12. 12
    Trocknenis dried (Na2SO4)
13. 13
    Sonstigethe ether removed
14. 14
    workup.DISTILLATIONthe residue distilled in vacuo

Vorschrift

Ethyldiethoxyacetate (32 g.) and methylacetate (25 g.) are placed in a flask equipped with stirrer and reflux condenser and heated to reflux. Metallic sodium wire (6.5 g.) is introduced into the flask in small portions and heating continued until the sodium is completely dissolved. Methylacetate (25 g.) and metallic sodium wire (6.5 g.) are then added and heating continued until the solution is clear. The mixture is cooled, a large volume of ice water cautiously added and the mixture extracted with ether. The aqueous solution is acidified with hydrochloric acid at 10° C. to 15° C. and the desired product extracted with ether. The ethereal extract is dried (Na2SO4), the ether removed and the residue distilled in vacuo to give methyl γ,γ-diethoxyacetoacetate.

Quelle