Reaktion #95220

Reaktionsgleichung

5-amino-3-trichloromethyl-1,2,4-thiadiazole

2-chlorobenzoyl chloride

→

crude product

Ausbeute 85.0%

5-(2-Chlorobenzamido)-3-Trichloromethyl-1,2,4-Thiadiazole

Ausbeute 85.0%

Lösungsmittel

xylene

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenAfter concentration in vacuo
2. 2
   Sonstigethe resulting oil was triturated with cold hexane

Vorschrift

A solution of 10.9 g (0.05 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 17.5 g (0.10 mole) 2-chlorobenzoyl chloride was heated at reflux for 18 hours in 200 ml xylene. After concentration in vacuo, the resulting oil was triturated with cold hexane to give 14.9 g (85% yield) of crude product. Recrystallization from benzene/hexane gave a pure product; m.p. 142° C.

Quelle