Reaktion #95218

Reaktionsgleichung

5-amino-3-trichloromethyl-1,2,4-thiadiazole

4-nitrobenzoyl chloride

→

pure product

Ausbeute 73.5%

5-(4-Nitrobenzamido)-3-Trichloromethyl-1,2,4-Thiadiazole

Ausbeute 73.5%

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturat reflux for 20 hours
2. 2
   Sonstigethe crude product precipitated from the reaction mixture
3. 3
   Sonstigewas isolated by filtration
4. 4
   WaschenAfter washing with hexane

Vorschrift

A solution of 10.9 g (0.05 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 10.2 g (0.055 mole) 4-nitrobenzoyl chloride in 200 ml toluene was heated at reflux for 20 hours. Upon cooling to room temperature, the crude product precipitated from the reaction mixture and was isolated by filtration. After washing with hexane, 13.5 g (73% yield) of pure product was obtained; m.p. 214° C.

Quelle