Reaktion #95215

Reaktionsgleichung

5-amino-3-trichloromethyl-1,2,4-thiadiazole

4-toluoyl chloride

→

crude product

5-(4-Toluamido)-3-Trichloromethyl-1,2,4-Thiadiazole

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturat reflux for 20 hours
2. 2
   SonstigeUnreacted amino compound was removed
3. 3
   Temperaturby cooling the reaction mixture
4. 4
   Filtrationfiltering the precipitate

Vorschrift

A solution of 11.0 g (0.05 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 8.0 g (0.05 mole) 4-toluoyl chloride in 250 ml toluene was heated at reflux for 20 hours. Unreacted amino compound was removed by cooling the reaction mixture and filtering the precipitate. Concentration of the filtrate in vacuo gave the crude product, which was purified by recrystallization from cyclohexane. Yield was 9.1 g (27%); m.p. 127° C.

Quelle