Reaktion #95214

Reaktionsgleichung

5-amino-3-trichloromethyl-1,2,4-thiadiazole

3-toluoyl chloride

→

pure product

Ausbeute 12.0%

5-(3-Toluamido)-3-Trichloromethyl-1,2,4-Thiadiazole

Ausbeute 12.0%

Lösungsmittel

xylene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturat reflux for 20 hours
2. 2
   Sonstigethe resulting precipitate removed by filtration
3. 3
   WaschenThe crude product was washed with petroleum ether
4. 4
   Sonstigerecrystallized twice from toluene

Vorschrift

A solution of 22.0 g (0.1 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 16.0 g (0.1 mole) 3-toluoyl chloride in 250 ml xylene was heated at reflux for 20 hours. The reaction mixture was cooled to room temperature and the resulting precipitate removed by filtration. The crude product was washed with petroleum ether and then recrystallized twice from toluene to obtain 4.0 g (12% yield) of pure product; m.p. 142° C.

Quelle