Reaktion #95194

ord-ec65866c75be4f978567e4f78a8a1742

Reaktionsgleichung

CCCn1c(C)c(-c2ccncc2)c2cc(OC(C)(C)C(=O)O)ccc21.Cl
2-methyl-2-[2-methyl-1-propyl-3-(4-pyridyl)-1H-indole-5-yloxy]propanoic acid hydrochloride
CN
methylamine
→
CCCn1c(C)c(-c2ccncc2)c2cc(OC(C)(C)C(=O)NC)ccc21
2-Methyl-2-[2-methyl-1-propyl-3-(4-pyridyl)-1H-indole-5-yloxy]-propanoic acid methylamide

Edukte

CCCn1c(C)c(-c2ccncc2)c2cc(OC(C)(C)C(=O)O)ccc21.Cl
2-methyl-2-[2-methyl-1-propyl-3-(4-pyridyl)-1H-indole-5-yloxy]propanoic acid hydrochloride
CN
methylamine

Reagenzien

Keine

Lösungsmittel

C1COCCO1
dioxane

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The above compound was prepared from 2-methyl-2-[2-methyl-1-propyl-3-(4-pyridyl)-1H-indole-5-yloxy]propanoic acid hydrochloride and methylamine in dioxane using a procedure analogous to that of Example 128.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04343811uspto-grants-1982_08