Reaktion #951216

Reaktionsgleichung

2-hydroxymethylene-3,3,6-trimethyl-1-indanone

(R)-1-hydrazino-2-propanol

water

toluene

→

(R)-1-(4,4,7-trimethyl-1,4-dihydro-indeno[2,1-c]pyrazol-1-yl)-propan-2-ol

Ausbeute 89.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenAfter concentration in a vacuum
2. 2
   Sonstigethe reaction mixture was purified by column chromatography on silica gel (ethyl acetate)

Vorschrift

A solution of 0.7g (3.5 mmol) of 2-hydroxymethylene-3,3,6-trimethyl-1-indanone, 0.37 g (4.1 mmol) of (R)-1-hydrazino-2-propanol and 50 mg of p-toluenesulfonic acid in 50 ml of anhydrous toluene was heated on a water separator for 2 hours. After concentration in a vacuum, the reaction mixture was purified by column chromatography on silica gel (ethyl acetate). 0.8 g (89%) of (R)-1-(4,4,7-trimethyl-1,4-dihydro-indeno[2,1-c]pyrazol-1-yl)-propan-2-ol was obtained as a yellow oil which was used directly in the next reaction.

Quelle