Reaktion #95088

Reaktionsgleichung

3-(3-nitrophenyl)-2-butenoic acid

1-methyldecylamine

ethyl chloroformate

→

title compound

N-(1-Methyldecyl)-3-(3-Nitrophenyl)-2-butenamide

Lösungsmittel

dichloromethane

dichloromethane

dichloromethane

triethylamine

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONThis was followed by the addition of a solution of 3.0 g
2. 2
   workup.STIRRINGStirring
3. 3
   workup.WAITwas continued overnight
4. 4
   Waschenthe the reaction mixture was washed successively with 1 N potassium carbonate, water and saturated sodium chloride
5. 5
   SonstigeThe resulting solution was dried
6. 6
   Sonstigeit was evaporated in vacuo
7. 7
   Sonstigeleaving an oil which

Vorschrift

To a stirred slurry of 5.2 g. of the 3-(3-nitrophenyl)-2-butenoic acid from Preparation 12 having a melting point of 208°-210° C., in 100 ml. of dichloromethane, was added 2.8 g. of triethylamine in 10 ml. of dichloromethane. This was followed by the addition of a solution of 3.0 g. of ethyl chloroformate in 20 ml. of dichloromethane, during 20 minutes. Stirring was continued for 30 minutes, and then a solution of 1-methyldecylamine in 20 ml. of dichloromethane was added dropwise during 25 minutes. Stirring was continued overnight, and the the reaction mixture was washed successively with 1 N potassium carbonate, water and saturated sodium chloride. The resulting solution was dried using sodium sulfate, and then it was evaporated in vacuo leaving an oil which solidified on trituration under petroleum ether. This afforded 4.9 g. of the title compound, m.p. 72.5°-74° C.

Quelle