Reaktion #95017

Reaktionsgleichung

2,3-dichloropyrazine

methanol

product

2-Amino-3-bromo-5-methylpyrazine

→

2-amino-3-n-propoxy-5-methylpyrazine

Lösungsmittel

n-propanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigedescribed in Preparation 43

Vorschrift

By replacing the 2,3-dichloropyrazine and anhydrous methanol used in Preparation 43 by equivalent quantities of the product of Step A and n-propanol and following the method described in Preparation 43, 2-amino-3-n-propoxy-5-methylpyrazine is obtained. The 2-amino group can be converted to the 2-hydroxy by the method described by Sharp et al, ibid., (see Route III) which when treated with phosphorus oxychloride by the method of Preparation 13, Step B, provides 2-chloro-3-n-propoxy-5-methylpyrazine.

Quelle