Reaktion #95014

Reaktionsgleichung

2,3-dichloropyrazine

morpholine

→

2-Chloro-3-morpholinopyrazine

Lösungsmittel

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture is cooled
2. 2
   Sonstigeevaporated to dryness at a water-bath temperature of 55° C
3. 3
   ExtraktionA chloroform solution of the residue is extracted twice with 0.1 M sodium hydroxide
4. 4
   Trocknendried over magnesium sulfate
5. 5
   Sonstigeevaporated
6. 6
   Sonstigeto leave the product

Vorschrift

A mixture of 2,3-dichloropyrazine (5 g., 0.034 mmole), morpholine (5.8 g., 0.067 mmole), and 50 ml. of dimethylformamide are heatd at 90°-120° C. for 6-14 hours, in an atmosphere of nitrogen. The reaction mixture is cooled and evaporated to dryness at a water-bath temperature of 55° C. A chloroform solution of the residue is extracted twice with 0.1 M sodium hydroxide, dried over magnesium sulfate and evaporated to leave the product.

Quelle