Reaktion #95013

Reaktionsgleichung

Sodium hydride

benzyl alcohol

2,3-dichloropyrazine

→

2-chloro-3-benzyloxypyrazine

Lösungsmittel

benzene

benzene

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture is refluxed for 20-60 hours
2. 2
   Temperaturcooled
3. 3
   Waschenwashed with water
4. 4
   Sonstigedried
5. 5
   Sonstigeevaporated
6. 6
   workup.DISTILLATIONthe product distilled in vacuo

Vorschrift

Sodium hydride (0.10 mole) is added to 0.10 mole of benzyl alcohol in 100 ml. dry benzene and the mixture is refluxed 1-2 hours. The cooled solution is treated with 0.10 mole of 2,3-dichloropyrazine in 100 ml. of benzene. The mixture is refluxed for 20-60 hours, cooled, washed with water, dried, and evaporated and the product distilled in vacuo to give 2-chloro-3-benzyloxypyrazine.

Quelle