Reaktion #95011

Reaktionsgleichung

2,3-dichloropyrazine

sodium

methanol

→

2-chloro-3-methoxypyrazine

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   ExtraktionThe product is extracted with ether or chloroform
2. 2
   Sonstigerecrystallized from a suitable solvent such as ethanol

Vorschrift

A mixture of 0.1 mole of 2,3-dichloropyrazine and 2.3 g. (0.1 mole) of sodium in 160 ml. of anhydrous methanol is refluxed 5-10 hours, and poured into water. The product is extracted with ether or chloroform and recrystallized from a suitable solvent such as ethanol to give pure 2-chloro-3-methoxypyrazine.

Quelle