Reaktion #95000

Reaktionsgleichung

trichloroacetamidine

potassium carbonate

ethyl-4-chloroacetoacetate

→

crude product

Ausbeute 36.1%

6-Chloromethyl-4-Hydroxy-2-Trichloromethylpyrimidine

Ausbeute 36.1%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe aqueous solution was filtered
2. 2
   Sonstigeto give a precipitate
3. 3
   WaschenThe precipitate was washed
4. 4
   Sonstigedried

Vorschrift

A mixture of 30.0 g (0.18 mole) trichloroacetamidine, 25.2 g (0.18 mole) potassium carbonate, 30.3 g (0.18 mole) ethyl-4-chloroacetoacetate and 400 ml water was stirred 18 hours. The aqueous solution was filtered and acidified with hydrochloric acid to give a precipitate. The precipitate was washed and dried to give 17.0 g (36% yield) of crude product. An analytical sample recrystallized from ligroin had mp 138°-144° C. The structure was confirmed via infrared and elemental analysis.

Quelle