Reaktion #9498

Reaktionsgleichung

(3-nitro-7-phenylquinolin-4-yl)-(2-phenoxyethyl)amine

→

N4-(2-phenoxyethyl)-7-phenylquinoline-3,4-diamine

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigefor three hours
2. 2
   FiltrationThe reaction mixture was filtered through a layer of CELITE
3. 3
   Filtrationfilter aid
4. 4
   Einengenthe filtrate was concentrated under reduced pressure
5. 5
   workup.DISSOLUTIONdissolved in toluene (2×25 mL)
6. 6
   Einengenconcentrated under reduced pressure

Vorschrift

A solution of (3-nitro-7-phenylquinolin-4-yl)-(2-phenoxyethyl)amine (7.25 g, 18.8 mmol) in methanol (150 mL) was added to a Parr vessel charged with 5% platinum on carbon (0.84 g), and the reaction was placed under hydrogen pressure (50 psi, 3.4×105 Pa) for three hours. The reaction mixture was filtered through a layer of CELITE filter aid, and the filtrate was concentrated under reduced pressure, dissolved in toluene (2×25 mL), and concentrated under reduced pressure to provide N4-(2-phenoxyethyl)-7-phenylquinoline-3,4-diamine as a yellow semi-solid.

Quelle