Reaktion #9497

Reaktionsgleichung

4-Chloro-3-nitro-7-phenylquinoline

2-phenoxyethylamine

→

(3-nitro-7-phenylquinolin-4-yl)-(2-phenoxyethyl)amine

Ausbeute 100.3%

Lösungsmittel

diethyl ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe crude solid was triturated with water (100 mL)
2. 2
   Sonstigeisolated by filtration
3. 3
   Sonstigeisolated by filtration
4. 4
   Sonstigedried for two hours in a vacuum oven at 40° C.

Vorschrift

4-Chloro-3-nitro-7-phenylquinoline (6.0 g, 21 mmol) was treated with 2-phenoxyethylamine (3.18 g, 23.2 mmol) according to the method described in Part A of Examples 125–135. The crude solid was triturated with water (100 mL), isolated by filtration, sonicated with diethyl ether, isolated by filtration, and dried for two hours in a vacuum oven at 40° C. to provide 8.12 g of (3-nitro-7-phenylquinolin-4-yl)-(2-phenoxyethyl)amine as a yellow solid.

Quelle