Reaktion #9495

Reaktionsgleichung

4-Chloro-3-nitro-7-phenylquinoline

1-(tert-butoxycarbonyl)-4-(aminomethyl)piperidine

→

tert-butyl 4-[(3-nitro-7-phenylquinolin-4-ylamino)methyl]piperidine-1-carboxylate

Ausbeute 94.3%

Lösungsmittel

diethyl ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe crude solid was triturated with water
2. 2
   Sonstigeisolated by filtration
3. 3
   Sonstigeisolated by filtration
4. 4
   Sonstigedried for four hours in a vacuum oven at 40° C.

Vorschrift

4-Chloro-3-nitro-7-phenylquinoline (8.35 g, 29.3 mmol) was treated with 1-(tert-butoxycarbonyl)-4-(aminomethyl)piperidine (7.54 g, 35.2 mmol) according to the method described in Part A of Examples 152–156. The crude solid was triturated with water, isolated by filtration, sonicated with diethyl ether, isolated by filtration, and dried for four hours in a vacuum oven at 40° C. to provide 12.78 g of tert-butyl 4-[(3-nitro-7-phenylquinolin-4-ylamino)methyl]piperidine-1-carboxylate as a yellow solid, mp 153–154° C.

Quelle