Reaktion #9494

Reaktionsgleichung

1-[3-(6-Bromo3-nitroquinolin-4-ylamino)propyl]pyrrolidin-2-one

3-Methoxypropionyl chloride

→

1-{3-[8-bromo-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}pyrrolidin-2-one

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe crude product obtained in Part D
2. 2
   Sonstigewas recrystallized from acetonitrile
3. 3
   WaschenThe crystals were washed with cold acetonitrile and diethyl ether
4. 4
   Sonstigedried in a vacuum oven at 60° C.

Vorschrift

1-[3-(6-Bromo3-nitroquinolin-4-ylamino)propyl]pyrrolidin-2-one was treated according to the methods described in Parts B, C, and D of Examples 152–156. 3-Methoxypropionyl chloride was used in Part C. The crude product obtained in Part D was recrystallized from acetonitrile. The crystals were washed with cold acetonitrile and diethyl ether and dried in a vacuum oven at 60° C. to provide 1-{3-[8-bromo-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}pyrrolidin-2-one as a light grey solid.

Quelle