Reaktion #94931

Reaktionsgleichung

carbon dioxide

cyanoacetic acid

4-hydroxy-4-phenylpiperidine

formaldehyde

→

2-[(4-Hydroxy-4-phenyl-1-piperidyl)methyl]propenenitrile

Lösungsmittel

dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwhile maintaining an internal temperature of 20°-25° C
2. 2
   workup.ADDITIONUpon complete addition
3. 3
   workup.ADDITIONwas added dropwise in approximately five minutes
4. 4
   Sonstigewas 28° C
5. 5
   workup.ADDITIONmixed with 100 ml
6. 6
   Sonstigeof methylene chloride, the organic phase separated
7. 7
   Waschenwashed with water and salt solution
8. 8
   SonstigeUpon removal of solvent the product
9. 9
   Sonstigewas obtained as an oil, 10.5 g

Vorschrift

A solution of cyanoacetic acid (4.3 g., 0.05 mole) in 15 ml. of dioxane was cooled with an ice bath, and 4-hydroxy-4-phenylpiperidine (8.8 g., 0.05 mole) added while maintaining an internal temperature of 20°-25° C. Upon complete addition and a further fifteen minutes of stirring 37% aqueous formaldehyde (9 gm., 0.10 mole) was added dropwise in approximately five minutes. When approximately half was added carbon dioxide evolution was observed, the maximum internal temperature was 28° C. The reaction mixture was stirred overnight, mixed with 100 ml. of methylene chloride, the organic phase separated, washed with water and salt solution. Upon removal of solvent the product was obtained as an oil, 10.5 g., in practically analytical purity.

Quelle