Reaktion #9493

ord-9bc5d76282ce46f99fc9bea711c2f243

Reaktionsgleichung

O=[N+]([O-])c1cnc2ccc(Br)cc2c1Cl
6-Bromo-4-chloro-3-nitroquinoline
Nc1ccc(Br)cc1
4-bromoaniline
NCCCN1CCCC1=O
1-(3-aminopropyl)pyrrolidin-2-one
O=C1CCCN1CCCNc1c([N+](=O)[O-])cnc2ccc(Br)cc12
1-[3-(6-bromo-3-nitroquinolin-4-ylamino)propyl]pyrrolidin-2-one
Ausbeute 87.8%

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

6-Bromo-4-chloro-3-nitroquinoline (50.62 g, 177.8 mmol), prepared from 4-bromoaniline according to the methods described in Parts A–D of Example 1, was treated with 1-(3-aminopropyl)pyrrolidin-2-one (27.5 mL, 196 mmol) according to the method described in Part E of Example 1 to provide 61.41 g of 1-[3-(6-bromo-3-nitroquinolin-4-ylamino)propyl]pyrrolidin-2-one as a solid.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07091214B2uspto-grants-2006_08