Reaktion #94924

Reaktionsgleichung

sodium hydroxide

4-methylthiophenol

potassium hydroxide

trifluorochloroethylene

→

4-(1,1,2-trifluoro-2-chloroethylthio)toluene

Lösungsmittel

water

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   ExtraktionThe final product was extracted with ether
2. 2
   Trocknenthe ether solution was dried
3. 3
   Sonstigethe solvent was evaporated
4. 4
   workup.DISTILLATIONThe residual oil was distilled at 120° C./1 mm

Vorschrift

A hot solution (60° C.) of 248 g (2 moles) of 4-methylthiophenol, 44.8 g of 85% potassium hydroxide, and 280 ml of acetone were placed in an autoclave. An amount of 256 g (2.2 moles) of trifluorochloroethylene was introduced in 1 h under pressure with agitation at 50°-55° C. After 1 h the reaction mixture was poured out in a solution of 1200 ml of water and 80 g (2 moles) of sodium hydroxide. The final product was extracted with ether, the ether solution was dried, and the solvent was evaporated. The residual oil was distilled at 120° C./1 mm.

Quelle