Reaktion #949000

Reaktionsgleichung

2-methyl-3-nitro-6-acetamidobenzoic acid

HCl

→

2-Methyl-3-nitro-6-aminobenzoic acid

Lösungsmittel

NaOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling to 10° C.
2. 2
   Filtrationthe precipitate which deposits is filtered off with suction
3. 3
   Waschenwashed with water
4. 4
   Sonstigedried under reduced pressure at 50° C

Vorschrift

450 ml of 2N NaOH are initially taken and 75.6 g (0.317 mol) of 2-methyl-3-nitro-6-acetamidobenzoic acid are added. The reaction mixture is then warmed to 95° C. and is stirred at this temperature for one hour. After cooling to 10° C., it is acidified by addition of 425 ml of 2N HCl, and the precipitate which deposits is filtered off with suction, washed with water and dried under reduced pressure at 50° C. Yield: 50.7 g (0.258 mol)=82% of theory, m.p.: 183°-184° C.

Quelle